The short answer is yes. When consumed into the body, CBD inhibits the enzyme cytochrome P450, which plays a key role in metabolising a large number of drugs. Some compounds in grapefruit have the same effect, which is why doctors often advise patients to avoid eating grapefruit before or after taking their medication. Through the inhibition of cytochrome P450, CBD may either increase or reduce the effects of other drugs. So although there are many claims about the health benefits of CBD, and it is non-addictive and does not produce a high, if you are taking other medications then the interactions with CBD may be a problem.
A negative CBD interaction
The effects of CBD on cytochrome P450 must not be ignored. In essence, the two cancel each other out. There has been research that shows cytochrome P450 enzymes metabolise CBD whilst it simultaneously functions as a ‘competitive inhibitor’ of those same enzymes. This means that CBD prevents the enzymes from metabolising other compounds, though this effect will differ from one person to the next, depending on the following factors:
– The method of consumption and the dosage of the CBD product.
– The unique physiology of the individual.
– The nature of the CBD product.
– The type of medication the individual takes.
Though a lower dosage of CBD is likely to have a lesser effect on the activity of the enzymes in question, there is no established cut-off dose below which CBD won’t interact with other medications. For this reason, it is difficult for doctors to recommend the taking of CBD when you are already taking other medications, particularly when those medications are protecting you against harmful things like epileptic seizures or the spread of cancer.
That said, CBD has shown promise as a way of treating and controlling these issues, so it can become a complex issue when deciding whether or not to take CBD. This is why it is advised that you consult with your doctors first when you are on medications for a pre-existing condition. They will either be able to offer you advice directly, or point you in the direction of someone who can. In any case, as the person who is organising and administering your treatment, it is important that they are made aware of any new elements you are adding into your treatment programme.
In any case, there is no doubt that CBD does react with other medications, and it is important to consider this before making the decision to take any CBD product.